The LYNX Study aims to better understand how cat allergen affects the immune system and how the immune system responds to allergy shots (immunotherapy). To do this, we need to determine the best types of samples (i.e., blood, fluid from your nose, cells from your lymph node) to collect AND the best timing to collect these samples. With this study, we can better identify what sample types are best to detect and analyze changes in the immune system in response to exposure to cats.
The LYNX Study plans to enroll 16 participants. Eight participants will be currently receiving allergy shots for more than a year, and eight will have never received them.
If you qualify, you’ll attend one screening visit, and if eligible, have three additional visits over about one month. During these visits, we’ll ask you about your health and allergies, and perform the following assessments:
| Screening | Medical history, physical exam, skin prick test for cat allergen. |
| Visit 0 | Intrademal test: A small amount of cat allergen is injected just under the skin of your arms. Blood samples for research purposes will be collected. |
| Visit 1 | Lymph node sample: We will collect calls from a lymph node in your armpit. You will be given a local anesthetic to prevent pain with the procedure. Blood samples for research purposes will also be collected. |
| Visit 2 | Lymph node sample (again), nasal sample using a small brush and paper strip, and a swab from inside your nose to collect cells from the back of the throat. Blood samples for research purposes will also be collected. |
| Visit 3 | A follow-up phone call. |
The results from these tests will help scientists learn more about how cat allergies affect lymph nodes and other immune cells.
Learn whether you might be eligible for LYNX.